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benzene

  CAS=71-43-2

Names & Synonyms

Name of Substance

  • Benzene

Superlist Name

  • Benzene
  • Benzene (including benzene from gasoline)
  • Benzene [UN1114] [Flammable liquid]
  • Benzol diluent
  • RCRA waste no. U109
  • UN1114

Synonyms

  • (6)Annulene
  • AI3-00808
  • Benzeen [Dutch]
  • Benzen [Polish]
  • Benzene
  • Benzene (ACGIH:OSHA)
  • Benzin
  • Benzin (Obs.)
  • Benzine
  • Benzine (Obs.)
  • Benzol
  • Benzol (OSHA)
  • Benzol 90
  • Benzole
  • Benzolene
  • Benzolo [Italian]
  • Bicarburet of hydrogen
  • CCRIS 70
  • Carbon oil
  • Caswell No. 077
  • Coal naphtha
  • Cyclohexatriene
  • EINECS 200-753-7
  • EPA Pesticide Chemical Code 008801
  • Fenzen [Czech]
  • HSDB 35
  • Mineral naphtha
  • Motor benzol
  • NCI-C55276
  • NSC 67315
  • Nitration benzene
  • Phene
  • Phenyl hydride
  • Polystream
  • Pyrobenzol
  • Pyrobenzole
  • RCRA waste number U019

Systematic Name

  • Benzene
  • Benzene, pure
File Locator
  • AIDSLINE
  • CANCERLIT
  • CCRIS
  • DART/ETIC
  • DSL
  • EINECS
  • EMIC
  • GENETOX
  • HSDB
  • IRIS
  • MEDLINE
  • MESH
  • MESH HEADING
  • RTECS
  • SUPERLIST
  • TOXLINE
  • TRI95
  • TRI96
  • TRI97
  • TSCAINV

Internet Locators

  • ATSDR TOXFAQS
  • EPA Envirofacts
  • NIOSH ICSC
  • NIOSH Pocket Guide

Superlist Locator

  • CA65
  • CAA1
  • CGB
  • DOT
  • HPV
  • IARC
  • MA
  • MI
  • MTL
  • NJ
  • NTPA
  • NTPT
  • PA
  • PAFA
  • PEL
  • PELS
  • REL
  • RQ
  • S110
  • TLV
  • TRI
  • WHMI

Other Registry Number

  • 174973-66-1
  • 54682-86-9
Benzene

3-D Benzene Molecule

C6H6

71-43-2

Stereo Image enlarge/bezene.MOL
requires CHIME plug-in to view

Authors: Anonymous

Source: TA:IARC monographs on the Evaluation of the Carcinogenic risk of chemicals to humans PG:93-148 YR:1982 IP: VI:29

Abstract:

Benzene has been tested in rats by intragastric administration and inhalation exposure, and in mice by skin application, inhalation exposure and subcutaneous injection; increase in the incidence of Zymbal-gland carcinomas. Anaemia, lymphocytopenia and bone-marrow hyperplasia; lymphoid tumours. Benzene does not induce specific gene mutations in bacterial systems or in Drosophila melanogaster; cytogenetic abnormalities (chromosomal aberrations and sister chromatid exchanges) in mammalian cells in vitro; micronucleus test; chromosomal aberrations in the bone-marrow cells. Exposure to benzene may damage the testis. Evidence from most studies in mice, rats, guinea-pigs and rabbits suggests that benzene is not teratogenic at doses that are fetotoxic and embryolethal. (1) Gasoline production, storage, transport, vending and combustion; (2) production of other chemicals from benzene; and (3) indirect production of benzene (e.g., in coke ovens); major source of benzene emissions into water. Chronic human exposure to benzene results in leucopenia, thrombocytopenia, anaemia or combinations of these; blood dyscrasias; pancytopenia; aplasia of the bone marrow. Benzene crosses the human placenta. There is a clear correlation between exposure to benzene and the appearance of chromosomal aberrations in the bone marrow and peripheral lymphocytes of individuals exposed to high levels of benzene (>100 ppm); aberrations have been reported following chronic exposures to as little as 10 ppm; Many case reports and case series have described the association of leukaemia with exposure to benzene, either alone or in combination with other chemicals. Most cases were acute myelogenous leukaemia; Two follow-up studies showed high incidences of leukaemia among individuals ascertained as cases of benzene haemopathy. A series of epidemiological studies, both cohort and case-control, showed statistically significant associations between leukaemia (predominantly myelogenous) and occupational exposure to benzene and benzene-containing solvents. There is limited evidence that benzene is carcinogenic in experimental animals. It is established that human exposure to commercial benzene or benzene-containing mixtures can cause damage to the haematopoietic system, including pancytopenia. The relationship between benzene exposure and the development of acute myelogenous leukaemia has been established in epidemiological studies. Reports linking exposure to benzene with other malignancies were considered to be inadequate for evaluation. There is sufficient evidence that benzene is carcinogenic to man. (SHORTENED)

CAS Registry Numbers:

 
71-43-2

Language: English

Entry Month: June, 1984

Year of Publication: 1982

Secondary Source ID: RISKLINE/1984060012


 

What is Lindane Anyway?

Polycyclic Aromatic Hydrocarbon

Carcinogen
Reproductive Toxin


Toxic by inhalation. Liquid irritant to skin and eyes. CNS narcotic and anaesthetic. Human carcinogen. Can damage blood components and cause severe anaemia and bleeding.

Harmful when absorbed through the skin.

INHALATION: Cancer hazard. Can cause blood disorders. Inhalation causes headaches, dizziness, drowsiness, and nausea, and may lead to unconsciousness.

OTHER TOXICITY DATA:  Acute toxicity of benzene results primarily from depression of the central nervous system (CNS). Inhalation of concentrations over 50 ppm can produce headache, lassitude, weariness, dizziness, drowsiness, or excitation. Exposure to very high levels can result in unconsciousness and death.

Long-term overexposure to benzene has been associated with certain types of leukemia in humans. In addition, the International Agency for Research on Cancer (IARC) and OSHA consider benzene to be a human carcinogen. Chronic exposures to benzene at levels of 100 ppm and below have been reported to cause adverse blood effects including anemia. Benzene exposure can occur by inhalation and absorption through the skin.

Inhalation and forced feeding studies of benzene in laboratory animals have produced a carcinogenic response in a variety of organs, including possibly leukemia, other adverse effects on the blood, chromosomal changes and some effects on the immune system. Exposure to benzene at levels up to 300 ppm did not produce birth defects in animal studies; however, exposure to the higher dosage levels (greater than 100 ppm) resulted in a reduction of body weight of the rat pups (fetotoxicity). Changes in the testes have been observed in mice exposed to benzene at 300 ppm, but reproductive performance was not altered in rats exposed to benzene at the same level.

Aspiration of this product into the lungs can cause chemical pneumonia and can be fatal. Aspiration into the lungs can occur while vomiting after ingestion of this product. Do not siphon by mouth.


Safety Card --BENZENE 71-43-2 CY1400000

Toxic, volatile, flammable liquid hydrocarbon biproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

 


EPA's IRIS

Benzene

Benzene Support Documents


Vermont SIRI MSDS Archive

RAIS Toxicity Summary for BENZENE

Eighth Report on Carcinogens

Amoco Chemical -- BENZENE (AMOCO/TOTAL) CAS 71-43-2
Safety Card --BENZENE 71-43-2 CY1400000
Safety Card -- BENZOL 71-43-2 CY1400000
Safety Card -- CYCLOHEXATRIENE 71-43-2 CY1400000
Fisher - Benzene, p.a. 71-43-2
Fisher - Benzene 71-43-2
Fisher - Benzene 71-43-2
Fisher - Benzene, spectrophotometric grade 71-43-2

[6] Annulene
Benzine
Benzol
Cyclohexatriene
Phene

Classification Code

  • Agricultural Chemical
  • Carcinogens
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation data
  • Out-dated pesticide
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor data

Superlist Classification Code

  • ATSDR Profile Priority List, rank : 5
  • Known to be a carcinogen
  • Overall Carcinogenic Evaluation: Group 1
  • Reportable Quantity (RQ) = 10 lb
  • TWA (0.5 ppm); STEL (2.5 ppm); skin; Confirmed human carcinogen
  • TWA see 1910.1028; Ceiling 25 mg/m3;

ChemIDplus

 

 

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