Names & Synonyms

Superlist Name

• Benzene, pentachloro-
• Pentachlorobenzene
• RCRA waste no. U183

Synonyms

• 1,2,3,4,5-Pentachlorobenzene
• 4-05-00-00669 (Beilstein Handbook Reference)
• BRN 1911550
• Benzene, pentachloro-
• CCRIS 5927
• EINECS 210-172-0
• HSDB 2863
• NSC 1857
• PCB
• Pentachlorobenzene
• QCB
• RCRA waste number U183

Systematic Name

• Benzene, pentachloro-
• Pentachlorobenzene

Classification Code

• Drug / Therapeutic Agent
• Fungicide, bactericide, wood preservative
• Fungicides, industrial
• Insecticides, organochlorine
• Reproductive Effect
• TSCA Flag: S [Subject to a proposed or final SNUR]
• TSCA Flag: T [Subject to a Section 4 test rule]
• Tumor data

Superlist Classification Code

• ATSDR Profile Priority List, rank : 146
• Reportable Quantity (RQ) = 10 lb

File Locator

• CANCERLIT
• CCRIS
• DART/ETIC
• DSL
• EINECS
• EMIC
• HSDB
• IRIS
• MEDLINE
• MESH
• RTECS
• SUPERLIST
• TOXLINE
• TSCAINV

Internet Locators

• EPA Envirofacts
• NIOSH ICSC

Superlist Locator

• MA
• NTPT
• PA
• RQ
• S110
  

1) Linder et al., 1980 Subchronic Rat Oral Bioassay (including weanlings) Critical Effect: Liver and kidney toxicity Defined Dose Levels: NOAEL= none NOAEL(ADJ)= LOAEL= 8.3 mg/kg-day LOAEL(ADJ)= 8.3 mg/kg-day Conversion Factors: none ------------ DISCUSSION OF PRINCIPAL AND SUPPORTING STUDIES -------- Linder, R., T. Scotti, J. Goldstein, K. McElroy and D. Walsh. 1980. Acute and subchronic toxicity of pentachlorobenzene. J. Environ. Pathol. Toxicol. 4: 183-196. This study utilized 8 experimental groups (3 male, 5 female) of 10 rats each. A statistically significant increase in kidney weights, a decreased heart weight, and an increase in hyaline droplets in proximal kidney tubules was noted in rats receiving 8.3 mg/kg/day. Female rats receiving the next highest dose, 18 mg/kg/day, and their offspring showed increased liver/body weight ratios. At higher doses (up to 72 mg/kg/day) animals of both sexes showed hepatocellular enlargement, increase in adrenal and kidney weights, increased WBC counts, and lowered RBC indices. Suckling pups of dams receiving 18 mg/kg/day and higher doses of pentachlorobenzene developed tremors. The lowest dose of 8.3 mg/kg/day is considered a LOAEL. Linder et al. (1980) published a chart on estimated dietary dosage of pentachlorobenzene from which a figure of 8.3 mg/kg/day was estimated for male rats receiving 125 ppm in the diet. The 1985 Health Assessment Document for Chlorinated Benzenes reports an estimated dosage of approximately 11 mg/kg/day calculated from the same data. ------------------- UNCERTAINTY AND MODIFYING FACTORS --------------- UNCERTAINTY FACTORS: The composite uncertainty factor of 10,000 represents 10 each for the expected interspecies and interhuman variability to the toxicity of this compound in lieu of specific data, 10 to extrapolate a subchronic effect level to its chronic counterpart, and 10 to drop the LOAEL into the expected range of a NOAEL. --------------------- ADDITIONAL COMMENTS / STUDIES ----------------- An ADI of 0.0167 mg/kg was reported in the 1980 Ambient Water Quality Criteria for Chlorinated Benzenes. This was based on a paper by Khera and Villaneuve (1975) dealing with reproductive effects of short-term (10 days) feeding in rats.

In rat and monkey metabolism studies, Engst et al. (1976) and Rozman et al. (1979) identified pentachlorophenol (classified as B2, probable human carcinogen) and 2,3,4,5-tetrachlorophenol as major metabolites of pentachlorobenzene. Other chlorinated phenols were also identified as metabolites. Pentachlorophenol has also been identified in the urine of rabbits administered pentachlorobenzene (Kohli et al., 1976).

Also see:

 Data From SRC PhysProp Database