.. /LINDANE/ IS ABSORBED THROUGH ALL PORTALS ...
[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. III-240]**PEER REVIEWED**

A 1% LINDANE CREAM (KWELL) WAS APPLIED TO SKIN OF 9 VOLUNTEERS, LEFT ON FOR 12 HR & WASHED OFF WITH SOAP & WATER. PLASMA CONCN INCR TO 10.3 NG/ML (RANGE 2-24 NG/ML).
[HOSLER J ET AL; J INVEST DERMATOL 74 (1): 51-3 (1980)]**PEER REVIEWED**


IN 18 MONTH-OLD INFANT FATALLY POISONED WITH LINDANE, ... STORED IN FAT ... IN RATS ... IT REACHES STORAGE EQUILIBRIUM WITHIN 2-3 WK AT DIETARY LEVELS OF 1font>

... TRANSPLACENTAL PASSAGE ... HAS BEEN ESTABLISHED ...
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer,1972-PRESENT. (Multivolume work).,p. V20 220 (1979)]**PEER REVIEWED**

LINDANE OR ITS METABOLITES WERE ADMIN BY GAVAGE TO RATS AT 8 MG/KG/DAY FOR 18 DAYS. NO LINDANE METABOLITES WERE FOUND IN INTESTINE OR FECES. ITS METABOLITES IN BLOOD, LIVER, KIDNEYS, SPLEEN, HEART, & BRAIN WERE IDENTIFIED. [ENGST R ET AL; J ENVIRON SCI HEALTH, PART B 11 (2): 95-117 (1976)]**PEER REVIEWED**

AFTER ADAPTATION OF RATS TO LINDANE, (14)C-LINDANE WAS ORALLY ADMIN. FAT, KIDNEY & MUSCULATURE WERE MAIN SITES OF DEPOSITION. PITUITARY & THYROID GLANDS HAD HIGHEST ACTIVITY. ... HALF OF ADMIN LINDANE WAS EXCRETED WITHIN 3 OR 4 DAYS ...
[Menzie, C.M. Metabolism of Pesticides, Update II. U.S. Department of the Interior, Fish Wildlife Service, Special Scientific Report - Wildlife No. 2l2.Washington, DC: U.S. Government Printing Office, 1978. 38]**PEER REVIEWED**

Normal level of lindane found in human blood: 0.0001 mg % or 0.001 ug/ml.
[Winek,C.L. Drug and Chemical Blood-Level Data 1985. Pittsburgh, PA: Allied Fischer Scientific, 1985.]**PEER REVIEWED**

Percutaneous absorption is usually greater when the drug /Kwell, 1% lotion/ is applied to the face, scalp, axillae, neck, scrotum, or damaged skin.
[American Society of Hospital Pharmacists. American Hospital Formulary Service - Drug Information 86. Bethesda, MD: American Society of Hospms,1986 (Plus Supplements, 1986). 1765]**PEER REVIEWED**

Twenty-four hours prior to necropsy, obese yellow A(vy)/a, lean pseudoagouti A(vy)/a, and lean black a/a phenotypes of (YS x VY) F(1) hybrid female mice were dosed po with 18 mg lindane (containing 55 uCi U(14)C lindane)/kg. Urine, feces, and expired air were sampled for analysis. Data indicated that metabolism of lindane and excretion of its metabolites by these mice differ significantly from those of rats that are resistant to lindane-induced hepatomas. Treatment of the mice with 160 ppm lindane in the diet appeared to saturate the elimination pathways and resulted in an increased tissue burden of the insecticide and its metabolites in the older animals.
[Chadwick RW et al; Journal of Toxicology and Environmental Health 20: 411-34 (1987)]**PEER REVIEWED**

... Appears to be stored in the fatty tissues primarily. The distribution of lindane was ... highest in the fatty tissue, followed by brain, kidney, muscle, lungs, heart, spleen, liver, and blood. Lindane has a propensity to accumulate in the brain more than the beta-HCH.
[Sullivan, J.B. Jr., G.R. Krieger (eds.). Hazardous Materials Toxicology-Clinical Principles of Environmental Health. Baltimore, MD: Williams and Wilkins, 1992. 1034]**PEER REVIEWED**

Concentrations of lindane in human breast milk are stated to be approximately 5-7 times higher than concentrations in the maternal blood or in umbilical cord blood. Older women tend to have higher lindane concentrations of HCH and lindane in placental and umbilical cord blood than younger women. It has also been noted that lindane concentrations increased in maternal blood during delivery and that during pregnancy higher concentrations have been found in fetal blood and fetal tissue as well as placenta and amniotic fluid compared to maternal fat tissue.
[Sullivan, J.B. Jr., G.R. Krieger (eds.). Hazardous Materials Toxicology-Clinical Principles of Environmental Health. Baltimore, MD: Williams and Wilkins, 1992. 1035]**PEER REVIEWED**

Prolonged urinary excretion of these compounds up to 120 hr post dermal application /has been demonstrated/.
[Sullivan, J.B. Jr., G.R. Krieger (eds.). Hazardous Materials Toxicology-Clinical Principles of Environmental Health. Baltimore, MD: Williams and Wilkins, 1992. 1037]**PEER REVIEWED**

Gastrointestinal lindane bioavailability depends upon the vehicle; in rats, some 80% was absorbed when lindane was given in oil, but only 6% was absorbed when lindane was suspended in water.
[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 859]**PEER REVIEWED**